Gentronix offers a range of screening options for the assessment of a test substance in the micronucleus test, and its potential to induce structural and numerical chromosomal damage.
Increases in micronuclei in the cytoplasm of interphase cells are indicative of either chromosome breaks (clastogens), or abnormal segregation of chromosomes during mitosis (aneugens). As such the in vitro micronucleus test can detect both the clastogenic and aneugenic modes of action for a test substance in a single endpoint. Furthermore, with modification to include FISH in the study design, this assay can be used to discriminate between these two mechanisms, helping support risk management and safety assessment.
Predictive Toxicology, Expertly Delivered