OECD 490 Mouse Lymphoma Assay Test

SERVICE INFORMATION

The OECD 490 Mouse Lymphoma Assay Test is one of the mammalian gene mutation assays available and is frequently utilised in most genotoxicity testing regulatory frameworks. Able to detect point mutations, clastogens, and, in some cases, aneugens, the mouse lymphoma assay can detect a broad spectrum of genotoxic effects.

The mouse lymphoma assay was previously included in OECD guideline 476 for mammalian cell gene mutation but was separated into the new OECD 490 guideline in 2015. Our study director has been working on mouse lymphoma assays for over 14 years, gaining extensive experience in running this study type within the industry.

If you would like more details on how Gentronix can support your project by conducting the OECD 490: Mouse Lymphoma Assay (MLA) Test, please contact a team member or submit an enquiry at enquiries@gentronix.co.uk.

Test systemL5178Y TK+/--3.7.2C
OECD guideline490
Test Format3 hr +/- S9, and extended exposure -S9
Duplicate cultures are used
Typical test item requirementsTypically 5 g
EndpointMammalian gene mutation

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