Project Description

24-well ‘Mini Ames’ Agar Based Screen

SERVICE INFORMATION

Using a microwell format, the Ames 24-well study provides predictivity of the OECD 471 Ames study in comparable conditions but using just 5% of the test item and is also conducted in solid agar. This makes the 24-well version of the Ames test highly amenable to screening, with TA98 & TA100 providing coverage for the vast majority of all know mutagenic substances.

Advantages for Screening

– Agar based, TA98 & TA100 ± S9
– Results comparable to full plate format
– Requires 20 mg compound
– Quick, cost effective, high quality results

24-well Test strainsTA98, TA100
Metabolic activationTypically, induced rat liver S9, other sources
available
Replicates3 Wells per test concentration
Typical test item requirements20mg
Study Duration< 3 Weeks
EndpointMutagenicity

Predictive Toxicology, Expertly Delivered

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