Project Description

Full Plate Ames

Gentronix offers a range of screening options to help our clients to assess the mutagenic potential of test substances in the Ames test.

SERVICE INFORMATION

Ames assays are bacterial reverse mutation assays that use a variety of Salmonella (or E. coli) strains to detect a range of point mutations and have high sensitivity when used in combination. The Ames test is the most established assay for detecting direct-acting mutagens and forms a key aspect of regulatory genotoxicity testing across industries. As such, an early stage prediction of Ames test outcome is a key step in assessing the toxicological hazard of test substances during development. Gentronix offers a range of service options to meet your project requirements.

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OECD 471 Ames Test StrainsTA98, TA100, TA1535, TA1537, TA102, TA97, TA97a, uvrA/pKM101, WP2 pKM101, WP2 uvrA
Metabolic activationTypically induced rat liver S9, though other
sources are available
Test FormatPlate incorporation, pre-incubation
Typical test item requirements350mg
Formulation AnalysisAvailable upon request
EndpointMutagenicity

Predictive Toxicology, Expertly Delivered

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