Full Plate Ames Test
Gentronix offers a range of screening options to help our clients to assess the mutagenic potential of test substances in the Ames test.
SERVICE INFORMATION
Ames assays, including the full plate Ames test, are bacterial reverse mutation assays that use a variety of Salmonella (or E. coli) strains to detect a range of point mutations and have high sensitivity when combined. The Ames test is the most established assay for detecting direct-acting mutagens and forms a key aspect of regulatory genotoxicity testing across industries. As such, an early-stage prediction of the Ames test outcome is a key step in assessing the toxicological hazard of test substances during development. Gentronix offers a range of service options to meet your project requirements.
If you would like more details on how Gentronix can support your project by conducting the Full Plate Ames Test, please contact a team member or submit an enquiry at enquiries@gentronix.co.uk.
| OECD 471 Ames Test Strains | TA98, TA100, TA1535, TA1537, TA102, TA97, TA97a, uvrA/pKM101, WP2 pKM101, WP2 uvrA |
| Metabolic activation | Typically induced rat liver S9, though other sources are available |
| Test Format | Plate incorporation, pre-incubation |
| Typical test item requirements | 350mg |
| Formulation Analysis | Available upon request |
| Endpoint | Mutagenicity |