OECD 474: In vivo Micronucleus Assay
A new offering from Gentronix is the rodent micronucleus assay, which will allow testing of clastogenicity and aneugenicity in vivo. The in vivo micronucleus assay is the most commonly used in vivo genotoxicity study type (e.g. pharmaceutical and agrochemical active ingredient registrations) and is typically used as a follow-up for in vitro micronucleus or in vitro chromosome aberration positives, to see if the in vitro activity is expressed in vivo.
Working within the facilities at Alderley Park, Gentronix is able to deliver guideline compliant GLP in vivo micronucleus studies. Together with GLP compliant analytical partners, both bioanalytical services to demonstrate systemic exposure and test item formulation analysis can be provided.
Our study director has many years’ previous experience with rodent micronucleus studies, as well as other study types such as Comet, as do many members of the team.
|Test species and strain||Wistar Han rat|
|Dosing regime||2 doses, 24 hours apart|
|Scoring||Bone marrow (slide scored) and peripheral blood (flow cytometry)|
|Primary study director||Julie Hayes|
|Typical test item requirements||10g|
Predictive Toxicology, Expertly Delivered