Project Description

OECD 474: In vivo Micronucleus Assay


A new offering from Gentronix is the rodent micronucleus assay, which will allow testing of clastogenicity and aneugenicity in vivo.  The in vivo micronucleus assay is the most commonly used in vivo genotoxicity study type (e.g. pharmaceutical and agrochemical active ingredient registrations) and is typically used as a follow-up for in vitro micronucleus or in vitro chromosome aberration positives, to see if the in vitro activity is expressed in vivo.

Working within the facilities at Alderley Park, Gentronix is able to deliver guideline compliant GLP in vivo micronucleus studies. Together with GLP compliant analytical partners, both bioanalytical services to demonstrate systemic exposure and test item formulation analysis can be provided.

Our study director has many years’ previous experience with rodent micronucleus studies, as well as other study types such as Comet, as do many members of the team.

Test species and strainWistar Han rat
OECD guideline474
Dosing regime2 doses, 24 hours apart
ScoringBone marrow (slide scored) and peripheral blood (flow cytometry)
Primary study directorJulie Hayes
Typical test item requirements10g
Learn more about study director Julie Hayes

Predictive Toxicology, Expertly Delivered