OECD 474: In Vivo Micronucleus Assay Test
SERVICE INFORMATION
An additional offering from Gentronix is the OECD 474: In Vivo Micronucleus Assay Test, which allows the testing of clastogenicity and aneugenicity in vivo. The in vivo micronucleus assay is the most commonly used in vivo genotoxicity study type (e.g., pharmaceutical and agrochemical active ingredient registrations). It is typically used as a follow-up for in vitro micronucleus or in vitro chromosome aberration positives to determine if the observed in vitro activity is expressed in vivo.
Working within the facilities at Alderley Park, Gentronix can deliver guideline-compliant GLP in vivo micronucleus studies. With GLP-compliant partners, analytical services to demonstrate systemic exposure and test item formulation analysis can also be provided.
Our study director and the team have many years of previous experience with rodent micronucleus studies.
If you would like more details on how Gentronix can support your project by conducting the OECD 474 In Vivo Micronucleus Assay Test, please contact a team member or submit an enquiry at enquiries@gentronix.co.uk.
| Test species and strain | Wistar Han rat |
| OECD guideline | 474 |
| Dosing regime | 2 doses, 24 hours apart |
| Scoring | Bone marrow (slide scored) |
| Formulation Analysis & Proof of Exposure | Available upon request |
| Endpoint | In vivo structural and nummercial chromosomal damage |