OECD 474 GLP In Vivo Micronucleus Assay Services


An additional offering from Gentronix is the OECD 474 rodent micronucleus assay, which allows the testing of clastogenicity and aneugenicity in vivo. The in vivo micronucleus assay is the most commonly used in vivo genotoxicity study type (e.g. pharmaceutical and agrochemical active ingredient registrations) and is typically used as a follow-up for in vitro micronucleus or in vitro chromosome aberration positives to determine if the observed in vitro activity is expressed in vivo.

Working within the facilities at Alderley Park, Gentronix is able to deliver guideline-compliant GLP in vivo micronucleus studies. Together with GLP compliant partners, analytical services to demonstrate systemic exposure and test item formulation analysis can also be provided.

Our study director and the team have many years of previous experience with rodent micronucleus studies.

Test species and strainWistar Han rat
OECD guideline474
Dosing regime2 doses, 24 hours apart
ScoringBone marrow (slide scored)
Formulation Analysis & Proof of ExposureAvailable upon request
EndpointIn vivo structural and nummercial chromosomal damage

Your Trusted Partner in Genotoxicity and Toxicology Services