OECD 432: Phototoxicity Test
SERVICE INFORMATION
Gentronix offers the in vitro 3T3 neutral red uptake (NRU) phototoxicity test to enable the assessment of test substance phototoxicity to human skin under OECD 432: Phototoxicity Test. Certain chemicals only develop cytotoxic properties following activation by exposure to light. The 3T3 NRU phototoxicity assay provides a quick and high-throughput assessment of cytotoxicity induced only after test substance exposure to UV light, compared to non-light exposed conditions.
The OECD 432 phototoxicity assay has been validated, and Gentronix has established laboratory proficiency. Services are available in GLP and non-GLP formats.
If you would like more details on how Gentronix can support your project through the conduct of OECD 432: Phototoxicity Test, please contact a team member or submit an enquiry at enquiries@gentronix.co.uk.
| OECD guideline | OECD 432 |
| What is being assessed | Photoactivation of chemical cytotoxicity |
| Why is this important | Chemical exposure to humans and the environment inevitably leads to the subsequent exposure to UV, especially for substance with topical exposure. Determining whether a chemical is photoactivated or not, is a key phase in understanding risk assessment and management. |
| Test System | Balb/c 3T3 mouse fibroblast |
| Test Item Requirements | 200 mg |
