OECD 432 Phototoxicity Test
SERVICE INFORMATION
Gentronix offers the in vitro 3T3 neutral red uptake (NRU) phototoxicity test to enable the assessment of test substance phototoxicity to human skin under OECD 432 Phototoxicity Test. Certain chemicals only develop cytotoxic properties following activation by exposure to light. The 3T3 NRU phototoxicity assay provides a quick and high-throughput assessment of cytotoxicity induced only after test substance exposure to UV light, compared to non-light exposed conditions.
The OECD 432 phototoxicity assay has been validated, and Gentronix has established laboratory proficiency. Services are available in GLP and non-GLP formats.
If you would like more details on how Gentronix can support your project through the conduct of OECD 432: Phototoxicity Test, please contact a team member or submit an enquiry at enquiries@gentronix.co.uk.
| OECD guideline | OECD 432 |
| What is being assessed | Photoactivation of chemical cytotoxicity |
| Why is this important | Chemical exposure to humans and the environment inevitably leads to the subsequent exposure to UV, especially for substance with topical exposure. Determining whether a chemical is photoactivated or not, is a key phase in understanding risk assessment and management. |
| Test System | Balb/c 3T3 mouse fibroblast |
| Test Item Requirements | 200 mg |
