MicroFlow Flow MNT: Advanced Multiflow Testing Services

SERVICE INFORMATION

Flow MNT – Conducted on a miniaturised format and using flow cytometry to score both micronuclei and cytotoxicity, the flow micronucleus assay provides a rapid prediction of the in vitro micronucleus test. The miniaturised format enables the study to be performed using far less test item than an OECD 487 study, and results in more responsive delivery timelines.

flow micronucleus diagram 2x

Advantages for Screening

– High throughput
– Clastogenic & Aneugenic detection
– Quick, cost effective, high quality results

Test Cell LineTK6
Metabolic activationTypically, induced rat liver S9, other sources
available.
3 hours (+S9) and 24 hours (-S9)
Short +S9
Long –S9
2 arm study
Typical test item requirements20 mg (ICH S2(R1)) - 50 mg (OECD 487)
Study Duration< 3 Weeks
EndpointMicronucleus Formation / Chromosomal Damage

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