MicroFlow Flow MNT Test
SERVICE INFORMATION
Conducted in a miniaturised format and using flow cytometry to score both micronuclei and cytotoxicity, the flow micronucleus assay provides a rapid prediction of the in vitro micronucleus test. The miniaturised format enables the study to be performed using far fewer test items than an OECD 487 study, resulting in more responsive delivery timelines.
If you would like more details on how Gentronix can support your project through the conduct of the Microflow (Flow MNT) test, please get in touch with a team member or submit an enquiry at enquiries@gentronix.co.uk.
Advantages for Screening
– High throughput
– Clastogen & Aneugen detection
– Quick, cost-effective, high-quality results
| Test Cell Line | TK6 |
| Metabolic activation | Typically, induced rat liver S9, other sources available. 3 hours (+S9) and 24 hours (-S9) Short +S9 Long –S9 2 arm study |
| Typical test item requirements | 20 mg (ICH S2(R1)) - 50 mg (OECD 487) |
| Study Duration | < 3 Weeks |
| Endpoint | Micronucleus Formation / Chromosomal Damage |