The in vitro micronucleus test (MNT) is a mainstay of most regulatory genotoxicity testing strategies and is used to detect in vitro clastogens and aneugens. In this regard, it complements the Ames test well, as, between the two study types, they detect all of the three major classes of genotoxin. Fluorescence In Situ Hybridisation (FISH) can also be conducted to differentiate predominantly clastogenic and aneugenic modes of action.
We have been conducting GLP in vitro MNT studies since 2014 in both isolated human lymphocytes and TK6 cells. We have a highly experienced team of scientists that have been running, scoring and study directing this assay type for many years.