Full time – with occasional weekend working required

Alderley Park, Cheshire

Due to the high demand for our Big Blue® transgenic rodent mutation assay services we are looking for an independent, experienced scientist with a background in genetic toxicology and/or molecular biology to join our team and assist in the conduct and running of Big Blue studies. This is a permanent, full-time role that is critical to the planned growth of our company.

About us

Gentronix is a specialist CRO, located at Alderley Park in the north-west UK. We are committed to helping our clients develop safer chemicals and medicines, using innovative screening platforms as well as GLP regulatory tests to detect hazard, to understand mode-of-action, and help manage risk.

Comprising of >35 toxicologists with a range of experiences from within the pharmaceutical, agrochemical and CRO industries, our team has extensive expertise in the fields of genetic and skin toxicology. We are committed to offering our employees the opportunity to train and develop within our organisation.

The benefits

  • Competitive salary, depending on experience (details available upon request)
  • Pension scheme offering an 8% employers contribution
  • 25 days annual leave plus bank holidays
  • Smart Hive employee benefits scheme
  • Flexible working in a company with great team spirit
  • Working closely with our team of highly committed scientists, you will have the opportunity to develop your skills as a toxicologist within a CRO environment.

One of the key priorities for Gentronix is to develop and retain staff within the business in order to build a strong and knowledgeable team.We offer training, personal development opportunities and routes for career progression across all our teams.

Your role

Reporting to the Team Leader of the Big Blue® team, you will work primarily as a senior scientist helping initially to deliver the in vitro phase (mutant frequency analysis phase) of regulatory and non-regulatory Big Blue® transgenic rodent studies conducted in accordance with OECD 488, whilst the in vivo component of the assay is run at an external CRO. Conducted in compliance with Good Laboratory Practice (GLP), the in vitro phase specifically involves processing rodent tissue to extract DNA, packaging the recovered transgene into a bacteriophage and then infecting a specific strain of E. coli to detect mutations in the Big Blue® transgene.

In addition, you will also receive training to enable you to act as the Principal Investigator and take responsibility for the management of the in vitro phase, working closely with the external Study Director to ensure adherence to GLP regulations and timely data interpretation and reporting back to the Study Sponsor. Additionally, you will play an important role in adapting methods to meet alternative study requirements as well as training/mentoring other members of the team in conjunction with the Team Leader.

Specifically, you will:

  • Be responsible for the timely and accurate conduct and reporting of the in vitro phase of GLPcompliant OECD 488 genotoxicity studies.
  • Following a period of training, act as the Principal Investigator; a single point of contact for the planning, execution, management, and reporting of the in vitro study phase, liaising with the Study Director, sponsors and third-party organisations to deliver high quality science and expertise.
  • Work closely with the Team Leader to oversee the development, refinement and implementation of new methodology and ensure proficiency studies are completed.
  • Be actively involved in supporting clients in the interpretation and follow-up strategies for the data generated in genotoxicity studies.
  • Need to maintain an awareness of current scientific and regulatory developments impacting on the conduct and interpretation of all studies within genetic toxicology.
  • Progress into the Study Director role for Big Blue studies once all components of the assay are validated for conduct in-house.
  • Be willing to work at weekends approximately once per month, within a 37.5 hour total working week.

About you

To join us as Senior Scientist, you will need:

  • A relevant science-/toxicology-based PhD ideally with a significant molecular biology or genetic toxicology component.
  • Prior experience of working in a GLP environment (CRO/pharmaceutical industry). Further GLP training will also be provided.
  • Hands-on laboratory experience of nucleic acid extraction, microbiology, and cell culture techniques.
  • To demonstrate excellent project management skills and the ability to juggle multiple projects concurrently.
  • Have excellent written and attention to detail skills; prior experience of report writing is advantageous, but not essential as further training will be given.
  • The ability to develop, refine and adapt methods and troubleshoot within an in vitro laboratory setting.
  • A sound understanding of the principles of toxicology, regulatory test guidelines and their interpretation. Most importantly, you will be able to demonstrate a clear enthusiasm for the application of these in the development of safer chemicals and medicines.
  • To be a good communicator, comfortable and competent in presenting scientific data and methodologies to both an expert and lay audience.
  • A desire to be strong team player.
  • A passion for assisting in training team members and sharing knowledge and experience.

Gentronix is an equal opportunity employer. We value diversity and are strongly committed to providing equal employment opportunities for all employees and all applicants for employment. Equal opportunities are the only acceptable way to conduct business and we believe that the more inclusive our environments are, the better our work will be.

To apply, please submit your CV and cover letter via the apply now button below

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