OECD 437: Bovine Corneal Opacity and Permeability Test (BCOP)

SERVICE INFORMATION

The OECD 437 BCOP test is an ex vivo method, using cows eye corneas, for the determination of test chemicals (substances or mixtures) that require classification or labelling in accordance with GHS. Test chemicals are exposed to corneas enabling categorisation using the LLBO irritancy score.

The OECD 437 BCOP test is currently undergoing validation and establishment of laboratory proficiency under OECD 437, with services then becoming available in both GLP and non-GLP formats.

We offer a high capacity , exceptional quality and rapid turnaround times to me our clients need.

FIND OUT MORE

For innovative solutions in both genetic toxicology and skin toxicology, contact us and see how we can help.

Or contact us on info@gentronix.co.uk or +44 (0) 1625 238700

MORE ABOUT OECD 437

For further details on how Gentronix can support the risk assessment of your materials, please take a look at our GLP Skin toxicology services.

OECD guidelineOECD 437
What is being assessedPotential for eye irritation and serious eye damage and GHS classification and labelling
Why is this importantDetermination of chemicals that require, and those are not require, classification or labelling for eye irritaton and damage is an important aspect of chemical risk assessment and registration.
Test SystemBovine cornea from commercial meat processing
Opacity: light transmission through cornea, quantified using opacimeter
Permeability: contracts dye penetration of corneal layers.
Test Item Requirements 5 g / 5 ml

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SKIN & OCULAR SAFETY SUPPORTING COSMETIC REGULATORY TESTING AS NON-ANIMAL ALTERNATIVES METHODS

Skin Toxicology
OECD 431 Skin Corrosion OECD 439 Skin Irritation

Ocular Toxicology
OECD 492 EpiOcular OECD 437 BCOP

Skin Sensitisation
OECD 442C DPRA OECD 442D KeratinoSensTM OECD 442E h-CLAT